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EPA Fluoride
Standards Database:
NRC Countdown Report #1
DIRECTORY: Health
> EPA Fluoride
Standards > NRC
Review > NRC Countdown
Fluoride Action Network
March 13, 2006
NRC Countdown Report #1
by Paul Connett, PhD
Executive Director, FAN
Dear All,
It appears that the National Academies' report (the NRC review)
on fluoride is "at the press." Here is a link to pre-order
the report: http://fermat.nap.edu/catalog/11571.html
The report is approximately 500 pages and is entitled: Fluoride
in Drinking Water: A Scientific Review of EPA's Standards. We anticipate
that the report will be released within the next two or three weeks.
As a prelude to this release we will be distributing several bulletins
to provide the background to this report - both political and scientific.
First, it is necessary for people who are new to this issue, to
know that there are two agencies in the US dealing with fluoride
in water: the CDC and the US EPA. Strangely, the FDA
has managed to keep out of this issue.
The CDC, on behalf of the US Public Health Service, is a huge promoter
of ADDING fluoride to the water at approximately 1 ppm, ostensibly
to fight tooth decay. They are so zealous in the promotion of this
policy that they even actively support mandatory fluoridation on
a statewide basis. This campaign is directed by the Division of
Oral Health at the CDC. As far as watch-dogging health effects are
concerned, this agency has a huge conflict of interest. To find
a health problem is to pass a judgment against their own long term
commitment to promoting this practice.
The US EPA has the job of determining what level of fluoride in
water is safe to drink. In other words they treat fluoride as a
contaminant. Their mandate is to determine at what level natural
fluoride has to be REMOVED. That level was raised
from 2 ppm to 4 ppm in 1985. This was greeted with huge consternation
by scientists at the US EPA, who believed - and documented - that
political
pressures had been brought to bear on administrators to do this.
We will discuss this documentation
in a future bulletin.
The NRC reviewed this 4 ppm standard in 1993 but the review panel
was stacked in favor of those supporting fluoridation. The chairman
was a consultant for the tobacco industry for over six years. The
report contained several errors and the executive summary gives
a far more sanguine view of the health issues than the detailed
chapters. Huge areas like fluoride's
impacts on the brain were not considered. The report recommended
further research on bone fractures and cancer, but little of this
research has been carried out or published.
Panel not to consider "benefits"
The current panel has been specifically told that they are not
to get involved with considerations of the "benefits"
of fluoridation. This is very important because it should remove
any notion of tempering their recommendations in order to "protect
the fluoridation program."
MCLG or MCL?
Although the water is somewhat muddied because the MCL and the
MCLG are both set at 4 ppm, the panel should not be concerning themselves
with the MCL (maximum contaminant level), but rather only the MCLG
(maximum contaminant level goal).
This is important. The MCLG is the ideal goal one would want in
order to protect everyone in society - including the most vulnerable
(e.g. infants,
the elderly, the sick, those with nutritional deficiencies - e.g.
iodine
- and those with impaired
kidney function) from fluoride's toxic effects. This goal may
be neither practical nor achievable, however it is still the task
of the NRC panel to come up with their best recommendation for this.
A key step in determining this MCLG will be selecting an appropriate
margin of safety, which will protect the most vulnerable members
of society, as listed above.
The MCL - a legally enforceable standard - should be left to the
US EPA. This standard is a compromise between the MCLG (determined
with the best scientific judgment) and the economic costs of removing
natural fluoride down to the chosen level. A good illustration of
the difference between the MCLG and the MCL is provided by the case
of arsenic. The MCLG for arsenic is set at zero, because arsenic
is a known human carcinogen. However, the MCL for arsenic is 10
ppb, because of the costs of removing natural arsenic down to this
level. Even setting the MCL at this level caused objections among
certain western states - because of the costs incurred.
How was the MCLG of 4 ppm derived?
There are three steps in the EPA's
1985 determination.
1) They considered that it would take 20 milligrams of fluoride
per day to increase someone's lifetime risk of contracting crippling
skeletal fluorosis (the only end point the EPA considered).
2) They applied a safety margin to this of 2.5 ostensibly to
protect all the members of the human population, including the
subsets listed above. 20 milligrams per day divided by 2.5 gives
a safe daily dose (for everyone) of 8 milligrams per day.
3) They then assumed that people drank a maximum of two liters
of water per day, which means that it is safe for everyone to
drink water at 4 milligrams per liter (i.e. 4 ppm). Two liters
per day at 4 milligrams per liter would give one a dose of 8 milligrams
per day.
Five questions
This derivation poses five questions. They are:
1) Is crippling skeletal fluorosis the most sensitive end point
of fluoride's toxic effects on bone and is bone the most sensitive
tissue to fluoride?
2) Will no damage occur to bone (or other tissues) at doses less
than 20 milligrams per day?
3) Is a safety margin of 2.5 adequate to protect the whole range
of sensitivity (again consider the subsets listed above) we can
expect in a human population to any toxic substance?
4) Is water the only
source of fluoride, and if it is not, should not an adjustment
be made to the 8 milligrams per day figure before moving on to
a safe level in water?
5) Is two liters of water the maximum amount of water drunk by
any American?
FAN's answers to these five questions
We have no way of knowing what answers the panel will give to these
five questions, however we have submitted our own
critique of EPA's methodology both to the NRC and to the pesticide
division of the EPA (the latter is using the 4 ppm MCLG in its
health risk assessment of Dow Agrosciences' request to use sulfuryl
fluoride as a fumigant on foods). Here then are FAN's answers:
1) Not only is bone not the most sensitive tissue to fluoride
but crippling
skeletal fluorosis is not the first toxic effect on bone.
2) Even if one accepts crippling skeletal fluorosis as the most
sensitive end point, even the NRC 1993 review acknowledged that
10
milligrams per day (not 20 milligrams per day) could lead
to this condition.
3) By no stretch of the imagination could any honest toxicologist
sanction the use of a safety margin of 2.5 to protect all the
subsets in a human population. A safety margin of at least 10
would be required, and even higher if we wanted to introduce an
extra safety margin for infants and young children whose developing
tissues are known to be more sensitive to toxic substances.
4) The EPA was wrong not to subtract from the 8 milligram per
day figure, the daily fluoride intake from other
sources such as dental products, pesticide
residues, food and beverages made with fluoridated water,
some foods naturally high in fluoride (e.g. sardines and tea)
and certain types of fluorinated
pharmaceuticals.
5) The EPA was clearly wrong - based even on their own publications
- with the assumption that people only drink 2 liters of water
per day. Some people drink as much as 5 liters a day or even higher.
The Institute of Medicine even recommends that adults drink three
liters of water per day.
If all the appropriate adjustments are made, the MCLG would have
to be lowered to 0.4 ppm at most.
In addition to these very basic calculations, there is another
route which could lead to the panel recommending a drastically lowered
MCLG. This would be the panel's judgment on the new
evidence pertaining to osteosarcoma
and fluoride exposure. If the panel concludes that the weight of
evidence of animal and human studies now points to a likely relationship
between young boys drinking water at 1 ppm, or less, during their
6th, 7th and 8th years, and an increased risk of osteosarcoma, a
rare and frequently fatal bone cancer, they would have to recommend
an MCLG of zero.
Thus, we have to wait and see how they handle the Bassin
thesis and, of course, the Douglass (Bassin's thesis adviser)
cover-up.
FAN provided the relevant
chapter of Bassin's thesis to the panel, and one of the panel
members went to Harvard University to read the whole thesis. Prior
to this, Douglass had submitted
to the panel the same report he had sent to his NIH funders, in
which he claimed that he had found no
relationship between fluoridated water and osteosarcoma, and
even cited Bassin's thesis as a reference to support that conclusion
- even though it totally contradicted his claims.
We now know that Bassin stands by her findings and that her work
has been accepted for publication. Douglass has claimed that a future
report that he would co-author with Hoover and Whitford would vindicate
his "position" - however, this has yet to materialize.
So what will the panel make of all this?
As the report is 500 pages long we can expect some very detailed
analysis of the literature which has emerged since the 1993 NRC
review. However, it would be tragic if a detailed analysis of the
literature was used to duck a strong recommendation to the US EPA
on the MCLG. Nor will it be helpful if the panel uses the inevitable
uncertainties - which always exist in epidemiological studies -
merely to recommend "further studies." The fact that those
governments around the world who practice and promote water fluoridation
have failed miserably to fund studies which seriously investigate
the connection between fluoridation and many potential and serious
end points, should not be used to shield this practice any longer.
This is especially so since very few American studies have resulted
from the recommendations from the 1993 NRC panel.
We strongly believe that the panel has been provided with enough
scientific information to conclude that, while it might be difficult
for the EPA to come up with an MCL, above which money should be
spent to REMOVE natural fluoride, that they have seen enough to
recommend an MCLG that would mean that this toxic substance not
be deliberately ADDED to the drinking water.
Hopefully, the stage will be set for focusing our future attention
with grappling with the problems of over-exposure to natural fluoride
and not artificial fluoride.
See also:
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